Thesis for the Degree of Master of Engineering
Hybrid Method of Electrophoretic and Electrostatic Deposition of Nanomaterials for Multifunctional Surfaces: Development of Antimicrobial and Hydrophobic Nanoparticle Bilayers to Prevent Pathogenic Bacteria Invasion
by
Hyunji Myung
In charge of major work: Young Soo Joung
June 2020
Department of Mechanical Systems Engineering
The Graduate School
Sookmyung Women's University
ABSTRACT
Airborne particulates can have a massive impact on human health. Particulate matter (PM) in city air contains components such as benzo[a]pyrene (BaP) that may cause inflammation or cancer. Additionally, ultrafine particles, which are less than 0.1µm in diameter, have been reported to cause more aggressive health problems than larger particulates. Therefore, to analyze and prevent respiratory diseases, it is necessary to identify the polluting hazards. To date, many studies have focused on the adverse effects of polycyclic aromatic hydrocarbons (PAHs), a significant component of urban air pollutants. PAHs are typically adsorbed onto the surface of carbon core in the air to exist in a more stable chemical structure. The specific inflammatory reactions and other effects caused by the inhalation carbon black (CB) particles loaded with BaP, at varying concentrations and particle sizes, have not been revealed. In this study, we investigated the inflammatory responses and lesions on human airway organoids and mouse lungs caused by particulates. The CB particles, containing BaP, used here were produced using an aerosol generation system, at a particle size of 0.1 µm and 2.5 µm. Organoids reflect the significant structural and functional properties of organs, and is a promising technology to complement in vivo studies. Herein, we discuss the pathological evidence supporting the similar responses to PMs, both in vivo and in vitro. Our results provide evidence to understand the respiratory response against fine dust, and to predict disease characteristics and drug responses in individual patients.
Keywords: particulate matter, carbon black, benzo[a]pyrene, airway organoid, mouse intranasal instillation, respiratory inflammation, fine dust.
http://www.dcollection.net/handler/sookmyung/000000069362